Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis

CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (n=7) and double (n=12) CEBPA mutation...

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Autores principales: Pabst, T, Eyholzer, M, Fos, J, Mueller, B U
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676545/
https://www.ncbi.nlm.nih.gov/pubmed/19277035
http://dx.doi.org/10.1038/sj.bjc.6604977
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author Pabst, T
Eyholzer, M
Fos, J
Mueller, B U
author_facet Pabst, T
Eyholzer, M
Fos, J
Mueller, B U
author_sort Pabst, T
collection PubMed
description CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (n=7) and double (n=12) CEBPA mutations among 224 AML patients. Double CEBPA mutations conferred a decisively favourable overall (P=0.006) and disease-free survival (P=0.013). However, clinical outcome of patients with single CEBPA mutations was not different from CEBPA wild-type patients. In a multivariable analysis, only double – but not single – CEBPA mutations were identified as independent prognostic factors. These findings indicate heterogeneity within AML patients with CEBPA mutations.
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spelling pubmed-26765452010-04-21 Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis Pabst, T Eyholzer, M Fos, J Mueller, B U Br J Cancer Genetics and Genomics CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (n=7) and double (n=12) CEBPA mutations among 224 AML patients. Double CEBPA mutations conferred a decisively favourable overall (P=0.006) and disease-free survival (P=0.013). However, clinical outcome of patients with single CEBPA mutations was not different from CEBPA wild-type patients. In a multivariable analysis, only double – but not single – CEBPA mutations were identified as independent prognostic factors. These findings indicate heterogeneity within AML patients with CEBPA mutations. Nature Publishing Group 2009-04-21 2009-03-10 /pmc/articles/PMC2676545/ /pubmed/19277035 http://dx.doi.org/10.1038/sj.bjc.6604977 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Pabst, T
Eyholzer, M
Fos, J
Mueller, B U
Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
title Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
title_full Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
title_fullStr Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
title_full_unstemmed Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
title_short Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
title_sort heterogeneity within aml with cebpa mutations; only cebpa double mutations, but not single cebpa mutations are associated with favourable prognosis
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676545/
https://www.ncbi.nlm.nih.gov/pubmed/19277035
http://dx.doi.org/10.1038/sj.bjc.6604977
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AT fosj heterogeneitywithinamlwithcebpamutationsonlycebpadoublemutationsbutnotsinglecebpamutationsareassociatedwithfavourableprognosis
AT muellerbu heterogeneitywithinamlwithcebpamutationsonlycebpadoublemutationsbutnotsinglecebpamutationsareassociatedwithfavourableprognosis

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