Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer–drug conjugate

Paclitaxel is a widely used chemotherapeutic agent; however, its therapeutic index is limited by low tumor exposure and high systemic exposure. Paclitaxel poliglumex (PPX) is macromolecular drug conjugate that links paclitaxel with a biodegradable polymer, poly-L-glutamic acid. PPX enhances tumor ex...

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Detalles Bibliográficos
Autores principales: Chipman, Stewart D, Oldham, Fred B, Pezzoni, Gabriella, Singer, Jack W
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676644/
https://www.ncbi.nlm.nih.gov/pubmed/17722272

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