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Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo
Protein cage nanoparticles have the potential to serve as multifunctional cell targeted, imaging and therapeutic platforms for broad applications in medicine. However, before they find applications in medicine, their biocompatibility in vivo needs to be demonstrated. We provide here baseline biodist...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676807/ https://www.ncbi.nlm.nih.gov/pubmed/18203438 |
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author | Kaiser, Coleen R Flenniken, Michelle L Gillitzer, Eric Harmsen, Ann L Harmsen, Allen G Jutila, Mark A Douglas, Trevor Young, Mark J |
author_facet | Kaiser, Coleen R Flenniken, Michelle L Gillitzer, Eric Harmsen, Ann L Harmsen, Allen G Jutila, Mark A Douglas, Trevor Young, Mark J |
author_sort | Kaiser, Coleen R |
collection | PubMed |
description | Protein cage nanoparticles have the potential to serve as multifunctional cell targeted, imaging and therapeutic platforms for broad applications in medicine. However, before they find applications in medicine, their biocompatibility in vivo needs to be demonstrated. We provide here baseline biodistribution information of two different spherical protein cage nanoplatforms, the 28 nm viral Cowpea chlorotic mottle virus (CCMV) and the 12 nm heat shock protein (Hsp) cage. In naïve and immunized mice both nanoplatforms show similar broad distribution and movement throughout most tissues and organs, rapid excretion, the absence of long term persistence within mice tissue and organs, and no overt toxicity after a single injection. These results suggest that protein cage based nanoparticles may serve as safe, biocompatible, nanoplatforms for applications in medicine. |
format | Text |
id | pubmed-2676807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26768072009-05-12 Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo Kaiser, Coleen R Flenniken, Michelle L Gillitzer, Eric Harmsen, Ann L Harmsen, Allen G Jutila, Mark A Douglas, Trevor Young, Mark J Int J Nanomedicine Original Research Protein cage nanoparticles have the potential to serve as multifunctional cell targeted, imaging and therapeutic platforms for broad applications in medicine. However, before they find applications in medicine, their biocompatibility in vivo needs to be demonstrated. We provide here baseline biodistribution information of two different spherical protein cage nanoplatforms, the 28 nm viral Cowpea chlorotic mottle virus (CCMV) and the 12 nm heat shock protein (Hsp) cage. In naïve and immunized mice both nanoplatforms show similar broad distribution and movement throughout most tissues and organs, rapid excretion, the absence of long term persistence within mice tissue and organs, and no overt toxicity after a single injection. These results suggest that protein cage based nanoparticles may serve as safe, biocompatible, nanoplatforms for applications in medicine. Dove Medical Press 2007-12 2007-12 /pmc/articles/PMC2676807/ /pubmed/18203438 Text en © 2007 Dove Medical Press Limited. All rights reserved |
spellingShingle | Original Research Kaiser, Coleen R Flenniken, Michelle L Gillitzer, Eric Harmsen, Ann L Harmsen, Allen G Jutila, Mark A Douglas, Trevor Young, Mark J Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
title | Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
title_full | Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
title_fullStr | Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
title_full_unstemmed | Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
title_short | Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
title_sort | biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676807/ https://www.ncbi.nlm.nih.gov/pubmed/18203438 |
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