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Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles
This paper highlights the importance of lipid-based colloidal carriers and their pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral administration. There are several examples of biomacromolecules used nowadays in the therapeutics, which are promising candida...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676808/ https://www.ncbi.nlm.nih.gov/pubmed/18203427 |
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author | Martins, Susana Sarmento, Bruno Ferreira, Domingos C Souto, Eliana B |
author_facet | Martins, Susana Sarmento, Bruno Ferreira, Domingos C Souto, Eliana B |
author_sort | Martins, Susana |
collection | PubMed |
description | This paper highlights the importance of lipid-based colloidal carriers and their pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral administration. There are several examples of biomacromolecules used nowadays in the therapeutics, which are promising candidates to be delivered by means of liposomes and lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). Several production procedures can be applied to achieve a high association efficiency between the bioactives and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. Generally, this can lead to improved bioavailability, or in case of oral administration a more consistent temporal profile of absorption from the gastrointestinal tract. Advantages and drawbacks of such colloidal carriers are also pointed out. This article describes strategies used for formulation of peptides and proteins, methods used for assessment of association efficiency and practical considerations regarding the toxicological concerns. |
format | Text |
id | pubmed-2676808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26768082009-05-12 Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles Martins, Susana Sarmento, Bruno Ferreira, Domingos C Souto, Eliana B Int J Nanomedicine Review This paper highlights the importance of lipid-based colloidal carriers and their pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral administration. There are several examples of biomacromolecules used nowadays in the therapeutics, which are promising candidates to be delivered by means of liposomes and lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). Several production procedures can be applied to achieve a high association efficiency between the bioactives and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. Generally, this can lead to improved bioavailability, or in case of oral administration a more consistent temporal profile of absorption from the gastrointestinal tract. Advantages and drawbacks of such colloidal carriers are also pointed out. This article describes strategies used for formulation of peptides and proteins, methods used for assessment of association efficiency and practical considerations regarding the toxicological concerns. Dove Medical Press 2007-12 2007-12 /pmc/articles/PMC2676808/ /pubmed/18203427 Text en © 2007 Dove Medical Press Limited. All rights reserved |
spellingShingle | Review Martins, Susana Sarmento, Bruno Ferreira, Domingos C Souto, Eliana B Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
title | Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
title_full | Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
title_fullStr | Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
title_full_unstemmed | Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
title_short | Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
title_sort | lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676808/ https://www.ncbi.nlm.nih.gov/pubmed/18203427 |
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