VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection

Microbicides are compounds that applied vaginally or rectally, protect the user from sexually transmitted infections. Although no commercial product is yet available, many candidates are under development. A leading candidate, VivaGel(™) (SPL7013 Gel) is the product of nanotechnology. The active ing...

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Detalles Bibliográficos
Autores principales: Rupp, Richard, Rosenthal, Susan L, Stanberry, Lawrence R
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676817/
https://www.ncbi.nlm.nih.gov/pubmed/18203424
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author Rupp, Richard
Rosenthal, Susan L
Stanberry, Lawrence R
author_facet Rupp, Richard
Rosenthal, Susan L
Stanberry, Lawrence R
author_sort Rupp, Richard
collection PubMed
description Microbicides are compounds that applied vaginally or rectally, protect the user from sexually transmitted infections. Although no commercial product is yet available, many candidates are under development. A leading candidate, VivaGel(™) (SPL7013 Gel) is the product of nanotechnology. The active ingredient is SPL7013, a dendrimer that was designed specifically with HIV and HSV antiviral activity and human safety in mind. SPL7013 has demonstrated efficacy against human immunodeficiency virus and herpes simplex virus in in vitro and animal models. VivaGel(™) appears to be well tolerated in both animals and humans. This review summarizes the studies of VivaGel(™) and its active ingredient, SPL7013.
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spelling pubmed-26768172009-05-12 VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection Rupp, Richard Rosenthal, Susan L Stanberry, Lawrence R Int J Nanomedicine Review Microbicides are compounds that applied vaginally or rectally, protect the user from sexually transmitted infections. Although no commercial product is yet available, many candidates are under development. A leading candidate, VivaGel(™) (SPL7013 Gel) is the product of nanotechnology. The active ingredient is SPL7013, a dendrimer that was designed specifically with HIV and HSV antiviral activity and human safety in mind. SPL7013 has demonstrated efficacy against human immunodeficiency virus and herpes simplex virus in in vitro and animal models. VivaGel(™) appears to be well tolerated in both animals and humans. This review summarizes the studies of VivaGel(™) and its active ingredient, SPL7013. Dove Medical Press 2007-12 2007-12 /pmc/articles/PMC2676817/ /pubmed/18203424 Text en © 2007 Dove Medical Press Limited. All rights reserved
spellingShingle Review
Rupp, Richard
Rosenthal, Susan L
Stanberry, Lawrence R
VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection
title VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection
title_full VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection
title_fullStr VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection
title_full_unstemmed VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection
title_short VivaGel(™) (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection
title_sort vivagel(™) (spl7013 gel): a candidate dendrimer – microbicide for the prevention of hiv and hsv infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676817/
https://www.ncbi.nlm.nih.gov/pubmed/18203424
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AT stanberrylawrencer vivagelspl7013gelacandidatedendrimermicrobicideforthepreventionofhivandhsvinfection

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