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Reducing the Activity and Secretion of Microbial Antioxidants Enhances the Immunogenicity of BCG

BACKGROUND: In early clinical studies, the live tuberculosis vaccine Mycobacterium bovis BCG exhibited 80% protective efficacy against pulmonary tuberculosis (TB). Although BCG still exhibits reliable protection against TB meningitis and miliary TB in early childhood it has become less reliable in p...

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Detalles Bibliográficos
Autores principales:	Sadagopal, Shanmugalakshmi, Braunstein, Miriam, Hager, Cynthia C., Wei, Jie, Daniel, Alexandria K., Bochan, Markian R., Crozier, Ian, Smith, Nathaniel E., Gates, Hiriam O., Barnett, Louise, Van Kaer, Luc, Price, James O., Blackwell, Timothy S., Kalams, Spyros A., Kernodle, Douglas S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677452/ https://www.ncbi.nlm.nih.gov/pubmed/19436730 http://dx.doi.org/10.1371/journal.pone.0005531

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