Counteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic Treatment

BACKGROUND: Lethal mutagenesis, or virus extinction promoted by mutagen-induced elevation of mutation rates of viruses, may meet with the problem of selection of mutagen-resistant variants, as extensively documented for standard, non-mutagenic antiviral inhibitors. Previously, we characterized a mut...

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Detalles Bibliográficos
Autores principales: Perales, Celia, Agudo, Rubén, Domingo, Esteban
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677667/
https://www.ncbi.nlm.nih.gov/pubmed/19436746
http://dx.doi.org/10.1371/journal.pone.0005554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677667/
https://www.ncbi.nlm.nih.gov/pubmed/19436746
http://dx.doi.org/10.1371/journal.pone.0005554

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