Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

BACKGROUND: The mechanisms through which aberrant α-synuclein (ASYN) leads to neuronal death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes, mutant ASYNs impair Chaperone Mediated Autophagy (CMA), a targeted lysosomal degradation pathway; however, whether this occurs in...

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Detalles Bibliográficos
Autores principales: Xilouri, Maria, Vogiatzi, Tereza, Vekrellis, Kostas, Park, David, Stefanis, Leonidas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677735/
https://www.ncbi.nlm.nih.gov/pubmed/19436756
http://dx.doi.org/10.1371/journal.pone.0005515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677735/
https://www.ncbi.nlm.nih.gov/pubmed/19436756
http://dx.doi.org/10.1371/journal.pone.0005515

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