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Structural basis for the sequence-dependent effects of platinum–DNA adducts

The differences in efficacy and molecular mechanisms of platinum based anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) have been hypothesized to be in part due to the differential binding affinity of cellular and damage recognition proteins to CP and OX adducts formed on adjacent guanines in g...

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Detalles Bibliográficos
Autores principales:	Ramachandran, Srinivas, Temple, Brenda R., Chaney, Stephen G., Dokholyan, Nikolay V.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677858/ https://www.ncbi.nlm.nih.gov/pubmed/19255091 http://dx.doi.org/10.1093/nar/gkp029

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