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Engineering transcription factors with novel DNA-binding specificity using comparative genomics

The transcriptional program for a gene consists of the promoter necessary for recruiting RNA polymerase along with neighboring operator sites that bind different activators and repressors. From a synthetic biology perspective, if the DNA-binding specificity of these proteins can be changed, then the...

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Detalles Bibliográficos
Autores principales:	Desai, Tasha A., Rodionov, Dmitry A., Gelfand, Mikhail S., Alm, Eric J., Rao, Christopher V.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677863/ https://www.ncbi.nlm.nih.gov/pubmed/19264798 http://dx.doi.org/10.1093/nar/gkp079

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