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Oxidative stress induces degradation of mitochondrial DNA

Mitochondrial DNA (mtDNA) is located in close proximity of the respiratory chains, which are the main cellular source of reactive oxygen species (ROS). ROS can induce oxidative base lesions in mtDNA and are believed to be an important cause of the mtDNA mutations, which accumulate with aging and in...

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Detalles Bibliográficos
Autores principales:	Shokolenko, Inna, Venediktova, Natalia, Bochkareva, Alexandra, Wilson, Glenn L., Alexeyev, Mikhail F.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677867/ https://www.ncbi.nlm.nih.gov/pubmed/19264794 http://dx.doi.org/10.1093/nar/gkp100

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