The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene

CHD8 is a chromatin remodeling ATPase of the SNF2 family. We found that depletion of CHD8 impairs cell proliferation. In order to identify CHD8 target genes, we performed a transcriptomic analysis of CHD8-depleted cells, finding out that CHD8 controls the expression of cyclin E2 (CCNE2) and thymidyl...

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Detalles Bibliográficos
Autores principales: Rodríguez-Paredes, M., Ceballos-Chávez, M., Esteller, M., García-Domínguez, M., Reyes, J. C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677868/
https://www.ncbi.nlm.nih.gov/pubmed/19255092
http://dx.doi.org/10.1093/nar/gkp101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677868/
https://www.ncbi.nlm.nih.gov/pubmed/19255092
http://dx.doi.org/10.1093/nar/gkp101

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