The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA

The molecular basis underlying the aberrant DNA-methylation patterns in human cancer is largely unknown. Altered DNA methyltransferase (DNMT) activity is believed to contribute, as DNMT expression levels increase during tumorigenesis. Here, we present evidence that the expression of DNMT3b is post-t...

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Detalles Bibliográficos
Autores principales: López de Silanes, Isabel, Gorospe, Myriam, Taniguchi, Hiroaki, Abdelmohsen, Kotb, Srikantan, Subramanya, Alaminos, Miguel, Berdasco, María, Urdinguio, Rocío G., Fraga, Mario F., Jacinto, Filipe V., Esteller, Manel
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677878/
https://www.ncbi.nlm.nih.gov/pubmed/19270063
http://dx.doi.org/10.1093/nar/gkp123

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