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MRE11 complex links RECQ5 helicase to sites of DNA damage

RECQ5 DNA helicase suppresses homologous recombination (HR) possibly through disruption of RAD51 filaments. Here, we show that RECQ5 is constitutively associated with the MRE11–RAD50–NBS1 (MRN) complex, a primary sensor of DNA double-strand breaks (DSBs) that promotes DSB repair and regulates DNA da...

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Detalles Bibliográficos
Autores principales:	Zheng, Lu, Kanagaraj, Radhakrishnan, Mihaljevic, Boris, Schwendener, Sybille, Sartori, Alessandro A., Gerrits, Bertran, Shevelev, Igor, Janscak, Pavel
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677886/ https://www.ncbi.nlm.nih.gov/pubmed/19270065 http://dx.doi.org/10.1093/nar/gkp147

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