Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

BACKGROUND: During skeletogenesis, protein levels of β-catenin in the canonical Wnt signaling pathway determine lineage commitment of skeletal precursor cells to osteoblasts and chondrocytes. Adenomatous polyposis coli (Apc) is a key controller of β-catenin turnover by down-regulating intracellular...

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Detalles Bibliográficos
Autores principales: Miclea, Razvan L, Karperien, Marcel, Bosch, Cathy AJ, van der Horst, Geertje, van der Valk, Martin A, Kobayashi, Tatsuya, Kronenberg, Henry M, Rawadi, Georges, Akçakaya, Pinar, Löwik, Clemens WGM, Fodde, Riccardo, Wit, Jan Maarten, Robanus-Maandag, Els C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678105/
https://www.ncbi.nlm.nih.gov/pubmed/19356224
http://dx.doi.org/10.1186/1471-213X-9-26

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