Mutation of a Single Residue Renders Human Tetherin Resistant to HIV-1 Vpu-Mediated Depletion

The recently identified restriction factor tetherin/BST-2/CD317 is an interferon-inducible trans-membrane protein that restricts HIV-1 particle release in the absence of the HIV-1 countermeasure viral protein U (Vpu). It is known that Tantalus monkey CV1 cells can be rendered non-permissive to HIV-1...

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Detalles Bibliográficos
Autores principales: Gupta, Ravindra K., Hué, Stéphane, Schaller, Torsten, Verschoor, Ernst, Pillay, Deenan, Towers, Greg J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678251/
https://www.ncbi.nlm.nih.gov/pubmed/19461879
http://dx.doi.org/10.1371/journal.ppat.1000443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678251/
https://www.ncbi.nlm.nih.gov/pubmed/19461879
http://dx.doi.org/10.1371/journal.ppat.1000443

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