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Mucosal Immunization of Cynomolgus Macaques with the VSVΔG/ZEBOVGP Vaccine Stimulates Strong Ebola GP-Specific Immune Responses

BACKGROUND: Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates. METHODOLOGY/PRINCIPAL FINDINGS: We demonstrate that the VSVΔG/ZEBOVGP vaccine given 28 days pre-challenge either intranasally (IN), orally (OR), or intramuscularly (IM) protects non-human...

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Detalles Bibliográficos
Autores principales:	Qiu, Xiangguo, Fernando, Lisa, Alimonti, Judie B., Melito, P. Leno, Feldmann, Friedericke, Dick, Daryl, Ströher, Ute, Feldmann, Heinz, Jones, Steven M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678264/ https://www.ncbi.nlm.nih.gov/pubmed/19440245 http://dx.doi.org/10.1371/journal.pone.0005547

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