Cargando…
Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment
PURPOSE: Combination treatment of inhaled corticosteroid (ICS) plus long-acting β2-agonist (LABA) is widely used as a maintenance regimen for the management of asthma. This study evaluated the effect of the β2-adrenergic receptor (ADRB2) polymorphism on lung function and asthma control with regular...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678690/ https://www.ncbi.nlm.nih.gov/pubmed/19430548 http://dx.doi.org/10.3349/ymj.2009.50.2.182 |
_version_ | 1782166843260141568 |
---|---|
author | Kim, Seung-Hyun Ye, Young-Min Hur, Gyu-Young Lee, Hyun-Young Jee, Young-Koo Lee, Seung-Ho Holloway, John W Park, Hae-Sim |
author_facet | Kim, Seung-Hyun Ye, Young-Min Hur, Gyu-Young Lee, Hyun-Young Jee, Young-Koo Lee, Seung-Ho Holloway, John W Park, Hae-Sim |
author_sort | Kim, Seung-Hyun |
collection | PubMed |
description | PURPOSE: Combination treatment of inhaled corticosteroid (ICS) plus long-acting β2-agonist (LABA) is widely used as a maintenance regimen for the management of asthma. This study evaluated the effect of the β2-adrenergic receptor (ADRB2) polymorphism on lung function and asthma control with regular use of combination treatment of an inhaled ICS plus LABA. MATERIALS AND METHODS: 43 Korean asthmatics who were symptomatic despite regular ICS use for at least 3 months were enrolled. For a 2-week run-in period, they received ICS (budesonide 800 µg/day) plus terbutaline (5 µg prn). as needed. During the 24-week active treatment period, they received budesonide 160 µg and formoterol 4.5 µg b.i.d. as maintenance and rescue medication. Pulmonary function and quality of life scores were monitored every 8 weeks; morning/evening peak expiratory flow meter (PEFR) was recorded daily. Patients were genotyped for ADRB2 Arg16Gly using single base extension methodology. RESULTS: During the run-in period, there were no significant between-group differences in lung function; after 8 weeks of active treatment, Arg/Arg patients had significantly higher forced expiratory volume in 1 secord (FEV(1)) and maximal mid-expiratory flow (MMEF) (p = 0.023 and p = 0.021, respectively), and better asthma control and quality of life after 24 weeks (p = 0.016 and p = 0.028, respectively). During treatment, there was a greater improvement in morning/evening PEFR in Arg/Arg patients. CONCLUSION: Asthmatic patients with the Arg/Arg genotype at codon 16 of ADRB2 achieve better asthma control with long-term regular use of combined budesonide and formoterol treatment, suggesting that the ADRB2 genotype may dictate choice of treatment strategy. |
format | Text |
id | pubmed-2678690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-26786902009-05-08 Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment Kim, Seung-Hyun Ye, Young-Min Hur, Gyu-Young Lee, Hyun-Young Jee, Young-Koo Lee, Seung-Ho Holloway, John W Park, Hae-Sim Yonsei Med J Original Article PURPOSE: Combination treatment of inhaled corticosteroid (ICS) plus long-acting β2-agonist (LABA) is widely used as a maintenance regimen for the management of asthma. This study evaluated the effect of the β2-adrenergic receptor (ADRB2) polymorphism on lung function and asthma control with regular use of combination treatment of an inhaled ICS plus LABA. MATERIALS AND METHODS: 43 Korean asthmatics who were symptomatic despite regular ICS use for at least 3 months were enrolled. For a 2-week run-in period, they received ICS (budesonide 800 µg/day) plus terbutaline (5 µg prn). as needed. During the 24-week active treatment period, they received budesonide 160 µg and formoterol 4.5 µg b.i.d. as maintenance and rescue medication. Pulmonary function and quality of life scores were monitored every 8 weeks; morning/evening peak expiratory flow meter (PEFR) was recorded daily. Patients were genotyped for ADRB2 Arg16Gly using single base extension methodology. RESULTS: During the run-in period, there were no significant between-group differences in lung function; after 8 weeks of active treatment, Arg/Arg patients had significantly higher forced expiratory volume in 1 secord (FEV(1)) and maximal mid-expiratory flow (MMEF) (p = 0.023 and p = 0.021, respectively), and better asthma control and quality of life after 24 weeks (p = 0.016 and p = 0.028, respectively). During treatment, there was a greater improvement in morning/evening PEFR in Arg/Arg patients. CONCLUSION: Asthmatic patients with the Arg/Arg genotype at codon 16 of ADRB2 achieve better asthma control with long-term regular use of combined budesonide and formoterol treatment, suggesting that the ADRB2 genotype may dictate choice of treatment strategy. Yonsei University College of Medicine 2009-04-30 2009-04-30 /pmc/articles/PMC2678690/ /pubmed/19430548 http://dx.doi.org/10.3349/ymj.2009.50.2.182 Text en © Copyright: Yonsei University College of Medicine 2009 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Seung-Hyun Ye, Young-Min Hur, Gyu-Young Lee, Hyun-Young Jee, Young-Koo Lee, Seung-Ho Holloway, John W Park, Hae-Sim Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment |
title | Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment |
title_full | Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment |
title_fullStr | Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment |
title_full_unstemmed | Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment |
title_short | Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment |
title_sort | effect of β2-adrenergic receptor polymorphism in asthma control of patients receiving combination treatment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678690/ https://www.ncbi.nlm.nih.gov/pubmed/19430548 http://dx.doi.org/10.3349/ymj.2009.50.2.182 |
work_keys_str_mv | AT kimseunghyun effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT yeyoungmin effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT hurgyuyoung effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT leehyunyoung effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT jeeyoungkoo effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT leeseungho effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT hollowayjohnw effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment AT parkhaesim effectofb2adrenergicreceptorpolymorphisminasthmacontrolofpatientsreceivingcombinationtreatment |