Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios

This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoo, Hanik K., Chung, Seockhoon, Hong, Jin Pyo, Kim, Boong-Nyun, Cho, Soo Churl
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2009
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678711/
https://www.ncbi.nlm.nih.gov/pubmed/19430570
http://dx.doi.org/10.3349/ymj.2009.50.2.304
_version_ 1782166848220954624
author Yoo, Hanik K.
Chung, Seockhoon
Hong, Jin Pyo
Kim, Boong-Nyun
Cho, Soo Churl
author_facet Yoo, Hanik K.
Chung, Seockhoon
Hong, Jin Pyo
Kim, Boong-Nyun
Cho, Soo Churl
author_sort Yoo, Hanik K.
collection PubMed
description This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.
format Text
id pubmed-2678711
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Yonsei University College of Medicine
record_format MEDLINE/PubMed
spelling pubmed-26787112009-05-08 Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios Yoo, Hanik K. Chung, Seockhoon Hong, Jin Pyo Kim, Boong-Nyun Cho, Soo Churl Yonsei Med J Brief Communication This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea. Yonsei University College of Medicine 2009-04-30 2009-04-30 /pmc/articles/PMC2678711/ /pubmed/19430570 http://dx.doi.org/10.3349/ymj.2009.50.2.304 Text en © Copyright: Yonsei University College of Medicine 2009 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Yoo, Hanik K.
Chung, Seockhoon
Hong, Jin Pyo
Kim, Boong-Nyun
Cho, Soo Churl
Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
title Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
title_full Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
title_fullStr Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
title_full_unstemmed Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
title_short Microsatellite Marker in Gamma - Aminobutyric Acid - A Receptor Beta 3 Subunit Gene and Autism Spectrum Disorders in Korean Trios
title_sort microsatellite marker in gamma - aminobutyric acid - a receptor beta 3 subunit gene and autism spectrum disorders in korean trios
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678711/
https://www.ncbi.nlm.nih.gov/pubmed/19430570
http://dx.doi.org/10.3349/ymj.2009.50.2.304
work_keys_str_mv AT yoohanikk microsatellitemarkeringammaaminobutyricacidareceptorbeta3subunitgeneandautismspectrumdisordersinkoreantrios
AT chungseockhoon microsatellitemarkeringammaaminobutyricacidareceptorbeta3subunitgeneandautismspectrumdisordersinkoreantrios
AT hongjinpyo microsatellitemarkeringammaaminobutyricacidareceptorbeta3subunitgeneandautismspectrumdisordersinkoreantrios
AT kimboongnyun microsatellitemarkeringammaaminobutyricacidareceptorbeta3subunitgeneandautismspectrumdisordersinkoreantrios
AT chosoochurl microsatellitemarkeringammaaminobutyricacidareceptorbeta3subunitgeneandautismspectrumdisordersinkoreantrios

Ejemplares similares