The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis

BACKGROUND: The pro-apoptotic protein Siva-1 functions in both extrinsic and intrinsic cell death signaling; however, the exact contribution of the endogenous Siva-1 to DNA damage-induced apoptosis is unclear. Using cisplatin, a chemotherapeutic drug, to induce DNA damage and cell death, we determin...

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Detalles Bibliográficos
Autores principales: Barkinge, John L., Gudi, Radhika, Sarah, Hawkins, Chu, Fei, Borthakur, Alip, Prabhakar, Bellur S., Prasad, Kanteti V.S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678867/
https://www.ncbi.nlm.nih.gov/pubmed/19240372
http://dx.doi.org/10.4103/1477-3163.45389

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