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Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents
Aberrant signaling through protein-tyrosine kinase (PTK)-dependent pathways is associated with several proliferative diseases. Accordingly, PTK inhibitors are being developed as new approaches for the treatment of certain cancers. Growth factor receptor bound protein 2 (Grb2) is an important downstr...
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| Formato: | Texto |
| Lenguaje: | English |
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Kluwer Academic Publishers
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678932/ https://www.ncbi.nlm.nih.gov/pubmed/19444322 http://dx.doi.org/10.1007/s10989-006-9014-7 |