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The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs

Monoclonal antibodies have been successfully utilized as cancer-targeting therapeutics and diagnostics, but the efficacies of these treatments are limited in part by the size of the molecules and non-specific uptake by the reticuloendothelial system. Peptides are much smaller molecules that can spec...

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Detalles Bibliográficos
Autores principales: Krumpe, Lauren R.H., Mori, Toshiyuki
Formato: Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678933/
https://www.ncbi.nlm.nih.gov/pubmed/19444323
http://dx.doi.org/10.1007/s10989-005-9002-3
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author Krumpe, Lauren R.H.
Mori, Toshiyuki
author_facet Krumpe, Lauren R.H.
Mori, Toshiyuki
author_sort Krumpe, Lauren R.H.
collection PubMed
description Monoclonal antibodies have been successfully utilized as cancer-targeting therapeutics and diagnostics, but the efficacies of these treatments are limited in part by the size of the molecules and non-specific uptake by the reticuloendothelial system. Peptides are much smaller molecules that can specifically target cancer cells and as such may alleviate complications with antibody therapy. Although many endogenous and exogenous peptides have been developed into clinical therapeutics, only a subset of these consists of cancer-targeting peptides. Combinatorial biological libraries such as bacteriophage-displayed peptide libraries are a resource of potential ligands for various cancer-related molecular targets. Target-binding peptides can be affinity selected from complex mixtures of billions of displayed peptides on phage and further enriched through the biopanning process. Various cancer-specific ligands have been isolated by in vitro, in vivo, and ex vivo screening methods. As several peptides derived from phage-displayed peptide library screenings have been developed into therapeutics in current clinical trials, which validates peptide-targeting potential, the use of phage display to identify cancer-targeting therapeutics should be further exploited.
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spelling pubmed-26789332009-05-13 The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs Krumpe, Lauren R.H. Mori, Toshiyuki Int J Pept Res Ther Article Monoclonal antibodies have been successfully utilized as cancer-targeting therapeutics and diagnostics, but the efficacies of these treatments are limited in part by the size of the molecules and non-specific uptake by the reticuloendothelial system. Peptides are much smaller molecules that can specifically target cancer cells and as such may alleviate complications with antibody therapy. Although many endogenous and exogenous peptides have been developed into clinical therapeutics, only a subset of these consists of cancer-targeting peptides. Combinatorial biological libraries such as bacteriophage-displayed peptide libraries are a resource of potential ligands for various cancer-related molecular targets. Target-binding peptides can be affinity selected from complex mixtures of billions of displayed peptides on phage and further enriched through the biopanning process. Various cancer-specific ligands have been isolated by in vitro, in vivo, and ex vivo screening methods. As several peptides derived from phage-displayed peptide library screenings have been developed into therapeutics in current clinical trials, which validates peptide-targeting potential, the use of phage display to identify cancer-targeting therapeutics should be further exploited. Kluwer Academic Publishers 2006-03-03 2006-03 /pmc/articles/PMC2678933/ /pubmed/19444323 http://dx.doi.org/10.1007/s10989-005-9002-3 Text en © Springer Science+Business Media, Inc. 2006
spellingShingle Article
Krumpe, Lauren R.H.
Mori, Toshiyuki
The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
title The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
title_full The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
title_fullStr The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
title_full_unstemmed The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
title_short The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs
title_sort use of phage-displayed peptide libraries to develop tumor-targeting drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678933/
https://www.ncbi.nlm.nih.gov/pubmed/19444323
http://dx.doi.org/10.1007/s10989-005-9002-3
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