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Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy
Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2. Genetic evidence also suggests a...
Autores principales: | Davé, Utpal P., Akagi, Keiko, Tripathi, Rati, Cleveland, Susan M., Thompson, Mary A., Yi, Ming, Stephens, Robert, Downing, James R., Jenkins, Nancy A., Copeland, Neal G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679194/ https://www.ncbi.nlm.nih.gov/pubmed/19461887 http://dx.doi.org/10.1371/journal.pgen.1000491 |
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