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Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the down-regulation of BST-2 from the cell surface. He...

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Detalles Bibliográficos
Autores principales:	Mitchell, Richard S., Katsura, Chris, Skasko, Mark A., Fitzpatrick, Katie, Lau, David, Ruiz, Autumn, Stephens, Edward B., Margottin-Goguet, Florence, Benarous, Richard, Guatelli, John C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679223/ https://www.ncbi.nlm.nih.gov/pubmed/19478868 http://dx.doi.org/10.1371/journal.ppat.1000450

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