The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells

HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of disease progression. While HIV replication is associated with CD4 depletion in general, plasma viremia by itself predicts the rate of CD4 loss only minimally in untreated patients. To resolve this paradox, I hyp...

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Detalles Bibliográficos
Autor principal: Wu, Yuntao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679705/
https://www.ncbi.nlm.nih.gov/pubmed/19409100
http://dx.doi.org/10.1186/1742-4690-6-41
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author Wu, Yuntao
author_facet Wu, Yuntao
author_sort Wu, Yuntao
collection PubMed
description HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of disease progression. While HIV replication is associated with CD4 depletion in general, plasma viremia by itself predicts the rate of CD4 loss only minimally in untreated patients. To resolve this paradox, I hypothesize the existence of a subpopulation of R5(X4-signaling )viruses. I also suggest that the gradual evolution and emergence of this subpopulation are largely responsible for the slow depletion of peripheral CD4 T cells.
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spelling pubmed-26797052009-05-09 The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells Wu, Yuntao Retrovirology Commentary HIV-mediated CD4 depletion is the hallmark of AIDS and is the most reliable predictor of disease progression. While HIV replication is associated with CD4 depletion in general, plasma viremia by itself predicts the rate of CD4 loss only minimally in untreated patients. To resolve this paradox, I hypothesize the existence of a subpopulation of R5(X4-signaling )viruses. I also suggest that the gradual evolution and emergence of this subpopulation are largely responsible for the slow depletion of peripheral CD4 T cells. BioMed Central 2009-05-01 /pmc/articles/PMC2679705/ /pubmed/19409100 http://dx.doi.org/10.1186/1742-4690-6-41 Text en Copyright © 2009 Wu; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Wu, Yuntao
The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
title The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
title_full The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
title_fullStr The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
title_full_unstemmed The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
title_short The co-receptor signaling model of HIV-1 pathogenesis in peripheral CD4 T cells
title_sort co-receptor signaling model of hiv-1 pathogenesis in peripheral cd4 t cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679705/
https://www.ncbi.nlm.nih.gov/pubmed/19409100
http://dx.doi.org/10.1186/1742-4690-6-41
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