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Metallothionein as an Anti-Inflammatory Mediator

The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. MT expression is induced/enhanced in various tissues by a number of physiological...

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Detalles Bibliográficos
Autores principales: Inoue, Ken-ichiro, Takano, Hirohisa, Shimada, Akinori, Satoh, Masahiko
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679981/
https://www.ncbi.nlm.nih.gov/pubmed/19436762
http://dx.doi.org/10.1155/2009/101659
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author Inoue, Ken-ichiro
Takano, Hirohisa
Shimada, Akinori
Satoh, Masahiko
author_facet Inoue, Ken-ichiro
Takano, Hirohisa
Shimada, Akinori
Satoh, Masahiko
author_sort Inoue, Ken-ichiro
collection PubMed
description The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. MT expression is induced/enhanced in various tissues by a number of physiological mediators. The cellular accumulation of MT depends on the availability of cellular zinc derived from the diet. MT modulates the binding and exchange/transport of heavy metals such as zinc, cadmium, or copper under physiological conditions and cytoprotection from their toxicities, and the release of gaseous mediators such as hydroxyl radicals or nitric oxide. In addition, MT reportedly affects a number of cellular processes, such as gene expression, apoptosis, proliferation, and differentiation. Given the genetic approach, the apparently healthy status of MT-deficient mice argues against an essential biological role for MT; however, this molecule may be critical in cells/tissues/organs in times of stress, since MT expression is also evoked/enhanced by various stresses. In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied. Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions.
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spelling pubmed-26799812009-05-12 Metallothionein as an Anti-Inflammatory Mediator Inoue, Ken-ichiro Takano, Hirohisa Shimada, Akinori Satoh, Masahiko Mediators Inflamm Review Article The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. MT expression is induced/enhanced in various tissues by a number of physiological mediators. The cellular accumulation of MT depends on the availability of cellular zinc derived from the diet. MT modulates the binding and exchange/transport of heavy metals such as zinc, cadmium, or copper under physiological conditions and cytoprotection from their toxicities, and the release of gaseous mediators such as hydroxyl radicals or nitric oxide. In addition, MT reportedly affects a number of cellular processes, such as gene expression, apoptosis, proliferation, and differentiation. Given the genetic approach, the apparently healthy status of MT-deficient mice argues against an essential biological role for MT; however, this molecule may be critical in cells/tissues/organs in times of stress, since MT expression is also evoked/enhanced by various stresses. In particular, because metallothionein (MT) is induced by inflammatory stress, its roles in inflammation are implied. Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions. Hindawi Publishing Corporation 2009 2009-05-11 /pmc/articles/PMC2679981/ /pubmed/19436762 http://dx.doi.org/10.1155/2009/101659 Text en Copyright © 2009 Ken-ichiro Inoue et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Inoue, Ken-ichiro
Takano, Hirohisa
Shimada, Akinori
Satoh, Masahiko
Metallothionein as an Anti-Inflammatory Mediator
title Metallothionein as an Anti-Inflammatory Mediator
title_full Metallothionein as an Anti-Inflammatory Mediator
title_fullStr Metallothionein as an Anti-Inflammatory Mediator
title_full_unstemmed Metallothionein as an Anti-Inflammatory Mediator
title_short Metallothionein as an Anti-Inflammatory Mediator
title_sort metallothionein as an anti-inflammatory mediator
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679981/
https://www.ncbi.nlm.nih.gov/pubmed/19436762
http://dx.doi.org/10.1155/2009/101659
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