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Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women

BACKGROUND: Hp(2) alleles of the haptoglobin α–chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might contribute to the increased oxidative stress an...

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Autores principales: Álvarez-Blasco, Francisco, Martínez-García, Ma Ángeles, Luque-Ramírez, Manuel, Parraza, Naiara, San Millán, José L., Escobar-Morreale, Héctor F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680028/
https://www.ncbi.nlm.nih.gov/pubmed/19440331
http://dx.doi.org/10.1371/journal.pone.0005606
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author Álvarez-Blasco, Francisco
Martínez-García, Ma Ángeles
Luque-Ramírez, Manuel
Parraza, Naiara
San Millán, José L.
Escobar-Morreale, Héctor F.
author_facet Álvarez-Blasco, Francisco
Martínez-García, Ma Ángeles
Luque-Ramírez, Manuel
Parraza, Naiara
San Millán, José L.
Escobar-Morreale, Héctor F.
author_sort Álvarez-Blasco, Francisco
collection PubMed
description BACKGROUND: Hp(2) alleles of the haptoglobin α–chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might contribute to the increased oxidative stress and low-grade chronic inflammation frequently associated with polycystic ovary syndrome, obesity, and abnormalities of glucose tolerance. METHODOLOGY/PRINCIPAL FINDINGS: Serum haptoglobin and the haptoglobin α–chain polymorphism were determined in 141 patients with polycystic ovary syndrome and 102 non-hyperandrogenic women. Of the whole group of 243 premenopausal women, 117 were obese and 51 showed abnormal glucose tolerance. Although serum haptoglobin concentrations were similar in PCOS patients and controls, the former presented with an increased frequency of Hp(2) alleles (62% vs. 52%, P = 0.023). Circulating haptoglobin levels increased with obesity (P<0.001), yet no association was found between obesity and haptoglobin genotypes. No differences were observed in haptoglobin levels or genotype frequencies depending on glucose tolerance. Fifty percent of the variation in serum haptoglobin concentrations was explained by the variability in serum C-reactive protein concentrations, BMI, insulin sensitivity and haptoglobin genotypes. CONCLUSIONS/SIGNIFICANCE: Serum haptoglobin concentrations in premenopausal women are largely dependent on the haptoglobin polymorphism and on the presence of obesity, with insulin resistance and chronic inflammation possibly modulating this relationship. The association of polycystic ovary syndrome with Hp(2) alleles suggests that the anti-oxidant and anti-inflammatory properties of haptoglobin may be reduced in these patients.
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spelling pubmed-26800282009-05-18 Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women Álvarez-Blasco, Francisco Martínez-García, Ma Ángeles Luque-Ramírez, Manuel Parraza, Naiara San Millán, José L. Escobar-Morreale, Héctor F. PLoS One Research Article BACKGROUND: Hp(2) alleles of the haptoglobin α–chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might contribute to the increased oxidative stress and low-grade chronic inflammation frequently associated with polycystic ovary syndrome, obesity, and abnormalities of glucose tolerance. METHODOLOGY/PRINCIPAL FINDINGS: Serum haptoglobin and the haptoglobin α–chain polymorphism were determined in 141 patients with polycystic ovary syndrome and 102 non-hyperandrogenic women. Of the whole group of 243 premenopausal women, 117 were obese and 51 showed abnormal glucose tolerance. Although serum haptoglobin concentrations were similar in PCOS patients and controls, the former presented with an increased frequency of Hp(2) alleles (62% vs. 52%, P = 0.023). Circulating haptoglobin levels increased with obesity (P<0.001), yet no association was found between obesity and haptoglobin genotypes. No differences were observed in haptoglobin levels or genotype frequencies depending on glucose tolerance. Fifty percent of the variation in serum haptoglobin concentrations was explained by the variability in serum C-reactive protein concentrations, BMI, insulin sensitivity and haptoglobin genotypes. CONCLUSIONS/SIGNIFICANCE: Serum haptoglobin concentrations in premenopausal women are largely dependent on the haptoglobin polymorphism and on the presence of obesity, with insulin resistance and chronic inflammation possibly modulating this relationship. The association of polycystic ovary syndrome with Hp(2) alleles suggests that the anti-oxidant and anti-inflammatory properties of haptoglobin may be reduced in these patients. Public Library of Science 2009-05-19 /pmc/articles/PMC2680028/ /pubmed/19440331 http://dx.doi.org/10.1371/journal.pone.0005606 Text en Alvarez-Blasco et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Álvarez-Blasco, Francisco
Martínez-García, Ma Ángeles
Luque-Ramírez, Manuel
Parraza, Naiara
San Millán, José L.
Escobar-Morreale, Héctor F.
Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
title Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
title_full Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
title_fullStr Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
title_full_unstemmed Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
title_short Role of Haptoglobin in Polycystic Ovary Syndrome (PCOS), Obesity and Disorders of Glucose Tolerance in Premenopausal Women
title_sort role of haptoglobin in polycystic ovary syndrome (pcos), obesity and disorders of glucose tolerance in premenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680028/
https://www.ncbi.nlm.nih.gov/pubmed/19440331
http://dx.doi.org/10.1371/journal.pone.0005606
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