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Accumulating Progenitor Cells in the Luminal Epithelial Cell Layer Are Candidate Tumor Initiating Cells in a Pten Knockout Mouse Prostate Cancer Model

The PSA-Cre;Pten-loxP/loxP mouse prostate cancer model displays clearly defined stages of hyperplasia and cancer. Here, the initial stages of hyperplasia development are studied. Immunohistochemical staining showed that accumulated pAkt(+) hyperplastic cells overexpress luminal epithelial cell marke...

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Detalles Bibliográficos
Autores principales:	Korsten, Hanneke, Ziel-van der Made, Angelique, Ma, Xiaoqian, van der Kwast, Theo, Trapman, Jan
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680948/ https://www.ncbi.nlm.nih.gov/pubmed/19461893 http://dx.doi.org/10.1371/journal.pone.0005662

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