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The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS)

Anthrax lethal toxin (LT) induces vascular insufficiency in experimental animals through unknown mechanisms. In this study, we show that neuronal nitric oxide synthase (nNOS) deficiency in mice causes strikingly increased sensitivity to LT, while deficiencies in the two other NOS enzymes (iNOS and e...

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Detalles Bibliográficos
Autores principales:	Moayeri, Mahtab, Crown, Devorah, Dorward, David W., Gardner, Don, Ward, Jerrold M., Li, Yan, Cui, Xizhong, Eichacker, Peter, Leppla, Stephen H.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680977/ https://www.ncbi.nlm.nih.gov/pubmed/19478875 http://dx.doi.org/10.1371/journal.ppat.1000456

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