BMI and Diabetes Risk in Singaporean Chinese

OBJECTIVE: Increased BMI is a robust risk factor for type 2 diabetes. Paradoxically, South Asians have relatively low BMIs despite their high prevalence of type 2 diabetes. We examined the association between BMI and incident type 2 diabetes because detailed prospective cohort data on this topic in...

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Detalles Bibliográficos
Autores principales: Odegaard, Andrew O., Koh, Woon-Puay, Vazquez, Gabrielle, Arakawa, Kazuko, Lee, Hin-Peng, Yu, Mimi C., Pereira, Mark A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681015/
https://www.ncbi.nlm.nih.gov/pubmed/19324946
http://dx.doi.org/10.2337/dc08-1674
Descripción
Sumario:OBJECTIVE: Increased BMI is a robust risk factor for type 2 diabetes. Paradoxically, South Asians have relatively low BMIs despite their high prevalence of type 2 diabetes. We examined the association between BMI and incident type 2 diabetes because detailed prospective cohort data on this topic in Asians are scarce. RESEARCH DESIGN AND METHODS: This study was a prospective analysis of 37,091 men and women aged 45–74 years in the Singapore Chinese Health Study, using Cox regression analysis. RESULTS: Risk of incident type 2 diabetes significantly increased beginning with BMIs 18.5–23.0 kg/m(2)(relative risk 2.47 [95% CI 1.75–3.48]) and continued in a monotonic fashion across the spectrum of BMI. Results were stronger for younger than for older adults. CONCLUSIONS: BMIs considered lean and normal in Singaporean Chinese are strongly associated with increased risk of incident type 2 diabetes. This association weakened with advanced age but remained significant.

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