Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes

OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Jensen, Dorte M., Korsholm, Lars, Ovesen, Per, Beck-Nielsen, Henning, Moelsted-Pedersen, Lars, Westergaard, Jes G., Moeller, Margrethe, Damm, Peter
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681038/
https://www.ncbi.nlm.nih.gov/pubmed/19265024
http://dx.doi.org/10.2337/dc08-2061
_version_ 1782167006376624128
author Jensen, Dorte M.
Korsholm, Lars
Ovesen, Per
Beck-Nielsen, Henning
Moelsted-Pedersen, Lars
Westergaard, Jes G.
Moeller, Margrethe
Damm, Peter
author_facet Jensen, Dorte M.
Korsholm, Lars
Ovesen, Per
Beck-Nielsen, Henning
Moelsted-Pedersen, Lars
Westergaard, Jes G.
Moeller, Margrethe
Damm, Peter
author_sort Jensen, Dorte M.
collection PubMed
description OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.
format Text
id pubmed-2681038
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-26810382010-06-01 Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes Jensen, Dorte M. Korsholm, Lars Ovesen, Per Beck-Nielsen, Henning Moelsted-Pedersen, Lars Westergaard, Jes G. Moeller, Margrethe Damm, Peter Diabetes Care Original Research OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes. American Diabetes Association 2009-06 2009-03-05 /pmc/articles/PMC2681038/ /pubmed/19265024 http://dx.doi.org/10.2337/dc08-2061 Text en © 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Jensen, Dorte M.
Korsholm, Lars
Ovesen, Per
Beck-Nielsen, Henning
Moelsted-Pedersen, Lars
Westergaard, Jes G.
Moeller, Margrethe
Damm, Peter
Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes
title Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes
title_full Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes
title_fullStr Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes
title_full_unstemmed Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes
title_short Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes
title_sort peri-conceptional a1c and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681038/
https://www.ncbi.nlm.nih.gov/pubmed/19265024
http://dx.doi.org/10.2337/dc08-2061
work_keys_str_mv AT jensendortem periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT korsholmlars periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT ovesenper periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT becknielsenhenning periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT moelstedpedersenlars periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT westergaardjesg periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT moellermargrethe periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes
AT dammpeter periconceptionala1candriskofseriousadversepregnancyoutcomein933womenwithtype1diabetes

Ejemplares similares