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Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals

OBJECTIVE: Low levels of physical activity appear to be associated with insulin resistance. However, the detailed associations of these complex relationships remain elusive. We examined the prospective associations between self-reported TV viewing time, objectively measured time spent sedentary, at...

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Detalles Bibliográficos
Autores principales: Ekelund, Ulf, Brage, Soren, Griffin, Simon J., Wareham, Nicholas J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681043/
https://www.ncbi.nlm.nih.gov/pubmed/19252168
http://dx.doi.org/10.2337/dc08-1895
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author Ekelund, Ulf
Brage, Soren
Griffin, Simon J.
Wareham, Nicholas J.
author_facet Ekelund, Ulf
Brage, Soren
Griffin, Simon J.
Wareham, Nicholas J.
author_sort Ekelund, Ulf
collection PubMed
description OBJECTIVE: Low levels of physical activity appear to be associated with insulin resistance. However, the detailed associations of these complex relationships remain elusive. We examined the prospective associations between self-reported TV viewing time, objectively measured time spent sedentary, at light-intensity activity, and at moderate- and vigorous-intensity physical activity (MVPA) with insulin resistance. RESEARCH DESIGN AND METHODS: In 192 individuals (81 men and 111 women) with a family history of type 2 diabetes, we measured physical activity and anthropometric and metabolic variables at baseline and after 1 year of follow-up in the ProActive UK trial. Physical activity was measured objectively by accelerometry. Insulin resistance was expressed as fasting insulin and the homeostasis model assessment score (HOMA-IR). RESULTS: Baseline MVPA was a significant predictor of fasting insulin at follow-up (β = −0.004 [95% CI −0.007 to −0.0001], P = 0.022), and the association approached significance for HOMA-IR (β = −0.003 [−0.007 to 0.000002], P = 0.052), independent of time spent sedentary, at light-intensity activity, sex, age, smoking status, waist circumference, and self-reported TV viewing. Time spent sedentary and at light-intensity activity were not significantly associated with insulin resistance. The change in MVPA between baseline and follow-up was inversely related to fasting insulin (β = −0.003 [−0.007 to −0.0003], P = 0.032) and the HOMA-IR score (β = −0.004 [−0.008 to −0.001], P = 0.015) at follow-up, after adjustment for baseline phenotype in addition to the same confounders as above. CONCLUSIONS: These results highlight the importance of promoting moderate-intensity activity such as brisk walking for improving insulin sensitivity and possibly other metabolic risk factors to prevent type 2 diabetes.
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spelling pubmed-26810432010-06-01 Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals Ekelund, Ulf Brage, Soren Griffin, Simon J. Wareham, Nicholas J. Diabetes Care Original Research OBJECTIVE: Low levels of physical activity appear to be associated with insulin resistance. However, the detailed associations of these complex relationships remain elusive. We examined the prospective associations between self-reported TV viewing time, objectively measured time spent sedentary, at light-intensity activity, and at moderate- and vigorous-intensity physical activity (MVPA) with insulin resistance. RESEARCH DESIGN AND METHODS: In 192 individuals (81 men and 111 women) with a family history of type 2 diabetes, we measured physical activity and anthropometric and metabolic variables at baseline and after 1 year of follow-up in the ProActive UK trial. Physical activity was measured objectively by accelerometry. Insulin resistance was expressed as fasting insulin and the homeostasis model assessment score (HOMA-IR). RESULTS: Baseline MVPA was a significant predictor of fasting insulin at follow-up (β = −0.004 [95% CI −0.007 to −0.0001], P = 0.022), and the association approached significance for HOMA-IR (β = −0.003 [−0.007 to 0.000002], P = 0.052), independent of time spent sedentary, at light-intensity activity, sex, age, smoking status, waist circumference, and self-reported TV viewing. Time spent sedentary and at light-intensity activity were not significantly associated with insulin resistance. The change in MVPA between baseline and follow-up was inversely related to fasting insulin (β = −0.003 [−0.007 to −0.0003], P = 0.032) and the HOMA-IR score (β = −0.004 [−0.008 to −0.001], P = 0.015) at follow-up, after adjustment for baseline phenotype in addition to the same confounders as above. CONCLUSIONS: These results highlight the importance of promoting moderate-intensity activity such as brisk walking for improving insulin sensitivity and possibly other metabolic risk factors to prevent type 2 diabetes. American Diabetes Association 2009-06 2009-02-27 /pmc/articles/PMC2681043/ /pubmed/19252168 http://dx.doi.org/10.2337/dc08-1895 Text en © 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Ekelund, Ulf
Brage, Soren
Griffin, Simon J.
Wareham, Nicholas J.
Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
title Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
title_full Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
title_fullStr Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
title_full_unstemmed Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
title_short Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals
title_sort objectively measured moderate- and vigorous-intensity physical activity but not sedentary time predicts insulin resistance in high-risk individuals
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681043/
https://www.ncbi.nlm.nih.gov/pubmed/19252168
http://dx.doi.org/10.2337/dc08-1895
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