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Clinical Risk Factors for Severe Clostridium difficile–associated Disease
Identifying patients who are at high risk for severe Clostridium difficile–associated disease (CDAD) early in the course of their infection may help clinicians improve outcomes. Therefore, we compared clinical features associated with severe versus nonsevere CDAD by retrospectively reviewing records...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681109/ https://www.ncbi.nlm.nih.gov/pubmed/19239754 http://dx.doi.org/10.3201/eid1503.080312 |
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author | Henrich, Timothy J. Krakower, Douglas Bitton, Asaf Yokoe, Deborah S. |
author_facet | Henrich, Timothy J. Krakower, Douglas Bitton, Asaf Yokoe, Deborah S. |
author_sort | Henrich, Timothy J. |
collection | PubMed |
description | Identifying patients who are at high risk for severe Clostridium difficile–associated disease (CDAD) early in the course of their infection may help clinicians improve outcomes. Therefore, we compared clinical features associated with severe versus nonsevere CDAD by retrospectively reviewing records of hospitalized patients whose fecal assays were positive for C. difficile toxin. Of 336 patients, 12.2% had severe disease and 10.1% died from all causes. Regression modeling showed the following to be significantly associated with severe CDAD (p<0.05): age >70 years (odds ratio [OR] 3.35), maximum leukocyte count >20,000 cells/mL (OR 2.77), minimum albumin level <2.5 g/dL (OR 3.44), maximum creatinine level >2 mg/dL (OR 2.47), small bowel obstruction or ileus (OR 3.06), and computed tomography scan showing colorectal inflammation (OR 13.54). These clinical and laboratory markers for severe disease may be useful for identifying patients at risk for serious outcomes or death. |
format | Text |
id | pubmed-2681109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26811092009-05-18 Clinical Risk Factors for Severe Clostridium difficile–associated Disease Henrich, Timothy J. Krakower, Douglas Bitton, Asaf Yokoe, Deborah S. Emerg Infect Dis Research Identifying patients who are at high risk for severe Clostridium difficile–associated disease (CDAD) early in the course of their infection may help clinicians improve outcomes. Therefore, we compared clinical features associated with severe versus nonsevere CDAD by retrospectively reviewing records of hospitalized patients whose fecal assays were positive for C. difficile toxin. Of 336 patients, 12.2% had severe disease and 10.1% died from all causes. Regression modeling showed the following to be significantly associated with severe CDAD (p<0.05): age >70 years (odds ratio [OR] 3.35), maximum leukocyte count >20,000 cells/mL (OR 2.77), minimum albumin level <2.5 g/dL (OR 3.44), maximum creatinine level >2 mg/dL (OR 2.47), small bowel obstruction or ileus (OR 3.06), and computed tomography scan showing colorectal inflammation (OR 13.54). These clinical and laboratory markers for severe disease may be useful for identifying patients at risk for serious outcomes or death. Centers for Disease Control and Prevention 2009-03 /pmc/articles/PMC2681109/ /pubmed/19239754 http://dx.doi.org/10.3201/eid1503.080312 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Henrich, Timothy J. Krakower, Douglas Bitton, Asaf Yokoe, Deborah S. Clinical Risk Factors for Severe Clostridium difficile–associated Disease |
title | Clinical Risk Factors for Severe Clostridium difficile–associated Disease |
title_full | Clinical Risk Factors for Severe Clostridium difficile–associated Disease |
title_fullStr | Clinical Risk Factors for Severe Clostridium difficile–associated Disease |
title_full_unstemmed | Clinical Risk Factors for Severe Clostridium difficile–associated Disease |
title_short | Clinical Risk Factors for Severe Clostridium difficile–associated Disease |
title_sort | clinical risk factors for severe clostridium difficile–associated disease |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681109/ https://www.ncbi.nlm.nih.gov/pubmed/19239754 http://dx.doi.org/10.3201/eid1503.080312 |
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