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Clinical Risk Factors for Severe Clostridium difficile–associated Disease

Identifying patients who are at high risk for severe Clostridium difficile–associated disease (CDAD) early in the course of their infection may help clinicians improve outcomes. Therefore, we compared clinical features associated with severe versus nonsevere CDAD by retrospectively reviewing records...

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Detalles Bibliográficos
Autores principales: Henrich, Timothy J., Krakower, Douglas, Bitton, Asaf, Yokoe, Deborah S.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681109/
https://www.ncbi.nlm.nih.gov/pubmed/19239754
http://dx.doi.org/10.3201/eid1503.080312
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author Henrich, Timothy J.
Krakower, Douglas
Bitton, Asaf
Yokoe, Deborah S.
author_facet Henrich, Timothy J.
Krakower, Douglas
Bitton, Asaf
Yokoe, Deborah S.
author_sort Henrich, Timothy J.
collection PubMed
description Identifying patients who are at high risk for severe Clostridium difficile–associated disease (CDAD) early in the course of their infection may help clinicians improve outcomes. Therefore, we compared clinical features associated with severe versus nonsevere CDAD by retrospectively reviewing records of hospitalized patients whose fecal assays were positive for C. difficile toxin. Of 336 patients, 12.2% had severe disease and 10.1% died from all causes. Regression modeling showed the following to be significantly associated with severe CDAD (p<0.05): age >70 years (odds ratio [OR] 3.35), maximum leukocyte count >20,000 cells/mL (OR 2.77), minimum albumin level <2.5 g/dL (OR 3.44), maximum creatinine level >2 mg/dL (OR 2.47), small bowel obstruction or ileus (OR 3.06), and computed tomography scan showing colorectal inflammation (OR 13.54). These clinical and laboratory markers for severe disease may be useful for identifying patients at risk for serious outcomes or death.
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spelling pubmed-26811092009-05-18 Clinical Risk Factors for Severe Clostridium difficile–associated Disease Henrich, Timothy J. Krakower, Douglas Bitton, Asaf Yokoe, Deborah S. Emerg Infect Dis Research Identifying patients who are at high risk for severe Clostridium difficile–associated disease (CDAD) early in the course of their infection may help clinicians improve outcomes. Therefore, we compared clinical features associated with severe versus nonsevere CDAD by retrospectively reviewing records of hospitalized patients whose fecal assays were positive for C. difficile toxin. Of 336 patients, 12.2% had severe disease and 10.1% died from all causes. Regression modeling showed the following to be significantly associated with severe CDAD (p<0.05): age >70 years (odds ratio [OR] 3.35), maximum leukocyte count >20,000 cells/mL (OR 2.77), minimum albumin level <2.5 g/dL (OR 3.44), maximum creatinine level >2 mg/dL (OR 2.47), small bowel obstruction or ileus (OR 3.06), and computed tomography scan showing colorectal inflammation (OR 13.54). These clinical and laboratory markers for severe disease may be useful for identifying patients at risk for serious outcomes or death. Centers for Disease Control and Prevention 2009-03 /pmc/articles/PMC2681109/ /pubmed/19239754 http://dx.doi.org/10.3201/eid1503.080312 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Henrich, Timothy J.
Krakower, Douglas
Bitton, Asaf
Yokoe, Deborah S.
Clinical Risk Factors for Severe Clostridium difficile–associated Disease
title Clinical Risk Factors for Severe Clostridium difficile–associated Disease
title_full Clinical Risk Factors for Severe Clostridium difficile–associated Disease
title_fullStr Clinical Risk Factors for Severe Clostridium difficile–associated Disease
title_full_unstemmed Clinical Risk Factors for Severe Clostridium difficile–associated Disease
title_short Clinical Risk Factors for Severe Clostridium difficile–associated Disease
title_sort clinical risk factors for severe clostridium difficile–associated disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681109/
https://www.ncbi.nlm.nih.gov/pubmed/19239754
http://dx.doi.org/10.3201/eid1503.080312
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