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Dynamic Causal Modeling of the Response to Frequency Deviants

This article describes the use of dynamic causal modeling to test hypotheses about the genesis of evoked responses. Specifically, we consider the mismatch negativity (MMN), a well-characterized response to deviant sounds and one of the most widely studied evoked responses. There have been several me...

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Detalles Bibliográficos
Autores principales: Garrido, Marta I., Kilner, James M., Kiebel, Stefan J., Friston, Karl J.
Formato: Texto
Lenguaje:English
Publicado: American Physiological Society 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681422/
https://www.ncbi.nlm.nih.gov/pubmed/19261714
http://dx.doi.org/10.1152/jn.90291.2008
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author Garrido, Marta I.
Kilner, James M.
Kiebel, Stefan J.
Friston, Karl J.
author_facet Garrido, Marta I.
Kilner, James M.
Kiebel, Stefan J.
Friston, Karl J.
author_sort Garrido, Marta I.
collection PubMed
description This article describes the use of dynamic causal modeling to test hypotheses about the genesis of evoked responses. Specifically, we consider the mismatch negativity (MMN), a well-characterized response to deviant sounds and one of the most widely studied evoked responses. There have been several mechanistic accounts of how the MMN might arise. It has been suggested that the MMN results from a comparison between sensory input and a memory trace of previous input, although others have argued that local adaptation, due to stimulus repetition, is sufficient to explain the MMN. Thus the precise mechanisms underlying the generation of the MMN remain unclear. This study tests some biologically plausible spatiotemporal dipole models that rest on changes in extrinsic top-down connections (that enable comparison) and intrinsic changes (that model adaptation). Dynamic causal modeling suggested that responses to deviants are best explained by changes in effective connectivity both within and between cortical sources in a hierarchical network of distributed sources. Our model comparison suggests that both adaptation and memory comparison operate in concert to produce the early (N1 enhancement) and late (MMN) parts of the response to frequency deviants. We consider these mechanisms in the light of predictive coding and hierarchical inference in the brain.
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spelling pubmed-26814222009-06-11 Dynamic Causal Modeling of the Response to Frequency Deviants Garrido, Marta I. Kilner, James M. Kiebel, Stefan J. Friston, Karl J. J Neurophysiol Articles This article describes the use of dynamic causal modeling to test hypotheses about the genesis of evoked responses. Specifically, we consider the mismatch negativity (MMN), a well-characterized response to deviant sounds and one of the most widely studied evoked responses. There have been several mechanistic accounts of how the MMN might arise. It has been suggested that the MMN results from a comparison between sensory input and a memory trace of previous input, although others have argued that local adaptation, due to stimulus repetition, is sufficient to explain the MMN. Thus the precise mechanisms underlying the generation of the MMN remain unclear. This study tests some biologically plausible spatiotemporal dipole models that rest on changes in extrinsic top-down connections (that enable comparison) and intrinsic changes (that model adaptation). Dynamic causal modeling suggested that responses to deviants are best explained by changes in effective connectivity both within and between cortical sources in a hierarchical network of distributed sources. Our model comparison suggests that both adaptation and memory comparison operate in concert to produce the early (N1 enhancement) and late (MMN) parts of the response to frequency deviants. We consider these mechanisms in the light of predictive coding and hierarchical inference in the brain. American Physiological Society 2009-05 2009-03-04 /pmc/articles/PMC2681422/ /pubmed/19261714 http://dx.doi.org/10.1152/jn.90291.2008 Text en Copyright © 2009, American Physiological Society This document may be redistributed and reused, subject to www.the-aps.org/publications/journals/funding_addendum_policy.htm (http://www.the-aps.org/publications/journals/funding_addendum_policy.htm) .
spellingShingle Articles
Garrido, Marta I.
Kilner, James M.
Kiebel, Stefan J.
Friston, Karl J.
Dynamic Causal Modeling of the Response to Frequency Deviants
title Dynamic Causal Modeling of the Response to Frequency Deviants
title_full Dynamic Causal Modeling of the Response to Frequency Deviants
title_fullStr Dynamic Causal Modeling of the Response to Frequency Deviants
title_full_unstemmed Dynamic Causal Modeling of the Response to Frequency Deviants
title_short Dynamic Causal Modeling of the Response to Frequency Deviants
title_sort dynamic causal modeling of the response to frequency deviants
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681422/
https://www.ncbi.nlm.nih.gov/pubmed/19261714
http://dx.doi.org/10.1152/jn.90291.2008
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