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Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats

BACKGROUND: Simvastatin has been shown to ameliorate pulmonary hypertension by several mechanisms in experimental animal models. In this study, we hypothesized that the major benefits of simvastatin in pulmonary hypertension occur via the heme oxygenase-1 pathway. METHODS: Simvastatin (10 mg/kgw/day...

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Detalles Bibliográficos
Autores principales:	Hsu, Hsao-Hsun, Ko, Wen-Je, Hsu, Jo-Yu, Chen, Jin-Shing, Lee, Yung-Chie, Lai, I-Rue, Chen, Chau-Fong
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681458/ https://www.ncbi.nlm.nih.gov/pubmed/19409105 http://dx.doi.org/10.1186/1465-9921-10-32

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