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The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

Exon junction complexes (EJCs) link nuclear splicing to key features of mRNA function including mRNA stability, translation, and localization. We analyzed the formation of EJCs by the spliceosome, the physiological EJC assembly machinery. We studied a comprehensive set of eIF4A3, MAGOH, and BTZ muta...

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Detalles Bibliográficos
Autores principales:	Gehring, Niels H., Lamprinaki, Styliani, Hentze, Matthias W., Kulozik, Andreas E.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682485/ https://www.ncbi.nlm.nih.gov/pubmed/19478851 http://dx.doi.org/10.1371/journal.pbio.1000120

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