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PhiC31 integrase induces a DNA damage response and chromosomal rearrangements in human adult fibroblasts

BACKGROUND: PhiC31 integrase facilitates efficient integration of transgenes into human and mouse genomes and is considered for clinical gene therapy. However recent studies have shown that the enzyme can induce various chromosomal abnormalities in primary human embryonic cells and mammalian cell li...

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Detalles Bibliográficos
Autores principales:	Liu, Jian, Skjørringe, Tina, Gjetting, Torben, Jensen, Thomas G
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682486/ https://www.ncbi.nlm.nih.gov/pubmed/19341467 http://dx.doi.org/10.1186/1472-6750-9-31

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