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Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion

The SLC30A8 gene codes for a pancreatic beta-cell-expressed zinc transporter, ZnT8. A polymorphism in the SLC30A8 gene is associated with susceptibility to type 2 diabetes, although the molecular mechanism through which this phenotype is manifest is incompletely understood. Such polymorphisms may ex...

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Detalles Bibliográficos
Autores principales:	Fu, Yi, Tian, Wei, Pratt, Emily B., Dirling, Lisa B., Shyng, Show-Ling, Meshul, Charles K., Cohen, David M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682581/ https://www.ncbi.nlm.nih.gov/pubmed/19479076 http://dx.doi.org/10.1371/journal.pone.0005679

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