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Genetic Deficiency of Itgb2 or ItgaL Prevents Autoimmune Diabetes Through Distinctly Different Mechanisms in NOD/LtJ Mice

OBJECTIVE: Insulitis is an important pathological feature of autoimmune diabetes; however, mechanisms governing the recruitment of diabetogenic T-cells into pancreatic islets are poorly understood. Here, we determined the importance of leukocyte integrins β(2)(Itgb2) and αL (ItgaL) in developing ins...

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Detalles Bibliográficos
Autores principales:	Glawe, John D., Patrick, D. Ross, Huang, Meng, Sharp, Christopher D., Barlow, Shayne C., Kevil, Christopher G.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682677/ https://www.ncbi.nlm.nih.gov/pubmed/19223596 http://dx.doi.org/10.2337/db08-0804

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