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Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice

OBJECTIVE: The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of β-cell mass. RESEARCH DESIGN AND METHODS: We analyzed the capacity of β-cell expansion in 1.5- and 8-month-old mice in response to a high-fat diet, after short-term treatment with the gluca...

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Detalles Bibliográficos
Autores principales:	Tschen, Shuen-Ing, Dhawan, Sangeeta, Gurlo, Tatyana, Bhushan, Anil
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682690/ https://www.ncbi.nlm.nih.gov/pubmed/19228811 http://dx.doi.org/10.2337/db08-1651

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