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Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia

OBJECTIVE: Components of insulin/IGF-1 receptor–mediated signaling pathways in pancreatic β-cells have been implicated in the development of diabetes, in part through the regulation of β-cell mass in vivo. Studies in vitro have shown that the protein Ras homolog enriched in brain (Rheb) plays a key...

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Detalles Bibliográficos
Autores principales:	Hamada, Suirin, Hara, Kenta, Hamada, Takeshi, Yasuda, Hisafumi, Moriyama, Hiroaki, Nakayama, Rika, Nagata, Masao, Yokono, Koichi
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682691/ https://www.ncbi.nlm.nih.gov/pubmed/19258434 http://dx.doi.org/10.2337/db08-0519

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