NNAT and DIRAS3 genes are paternally expressed in pigs

Although expression and epigenetic differences of imprinted genes have been extensively characterised in man and the mouse, little is known on livestock species. In this study, the polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs...

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Detalles Bibliográficos
Autores principales: Cheng, Huan-Chen, Zhang, Feng-Wei, Deng, Chang-Yan, Jiang, Cao-De, Xiong, Yuan-Zhu, Li, Feng-E, Lei, Ming-Gang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682808/
https://www.ncbi.nlm.nih.gov/pubmed/17897599
http://dx.doi.org/10.1186/1297-9686-39-5-599
Descripción
Sumario:Although expression and epigenetic differences of imprinted genes have been extensively characterised in man and the mouse, little is known on livestock species. In this study, the polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1 )hybrids. The results show that both genes were paternally expressed in all the tested tissues (heart, liver, spleen, lung, kidney, stomach, small intestine, skeletal muscle, fat, uterus, ovary and pituitary). In addition, the NNAT gene had two transcripts in all tested tissues, which is consistent with its counterpart in man and cattle.

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