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Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation

Integrins are heterodimeric adhesion receptors that regulate immune cell adhesion. Integrin-dependent adhesion is controlled by multiple conformational states that include states with different affinity to the ligand, states with various degrees of molecule unbending, and others. Affinity change and...

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Detalles Bibliográficos
Autores principales:	Chigaev, Alexandre, Waller, Anna, Amit, Or, Halip, Liliana, Bologa, Cristian G., Sklar, Larry A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Molecular Basis of Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682882/ https://www.ncbi.nlm.nih.gov/pubmed/19251697 http://dx.doi.org/10.1074/jbc.M901178200

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