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The impact of cellular networks on disease comorbidity

The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease-...

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Detalles Bibliográficos
Autores principales: Park, Juyong, Lee, Deok-Sun, Christakis, Nicholas A, Barabási, Albert-László
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683720/
https://www.ncbi.nlm.nih.gov/pubmed/19357641
http://dx.doi.org/10.1038/msb.2009.16
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author Park, Juyong
Lee, Deok-Sun
Christakis, Nicholas A
Barabási, Albert-László
author_facet Park, Juyong
Lee, Deok-Sun
Christakis, Nicholas A
Barabási, Albert-László
author_sort Park, Juyong
collection PubMed
description The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease--gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population-level data and cellular network information could help build novel hypotheses about disease mechanisms.
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spelling pubmed-26837202009-05-18 The impact of cellular networks on disease comorbidity Park, Juyong Lee, Deok-Sun Christakis, Nicholas A Barabási, Albert-László Mol Syst Biol Report The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease--gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population-level data and cellular network information could help build novel hypotheses about disease mechanisms. Nature Publishing Group 2009-04-07 /pmc/articles/PMC2683720/ /pubmed/19357641 http://dx.doi.org/10.1038/msb.2009.16 Text en Copyright © 2009, EMBO and Nature Publishing Group
spellingShingle Report
Park, Juyong
Lee, Deok-Sun
Christakis, Nicholas A
Barabási, Albert-László
The impact of cellular networks on disease comorbidity
title The impact of cellular networks on disease comorbidity
title_full The impact of cellular networks on disease comorbidity
title_fullStr The impact of cellular networks on disease comorbidity
title_full_unstemmed The impact of cellular networks on disease comorbidity
title_short The impact of cellular networks on disease comorbidity
title_sort impact of cellular networks on disease comorbidity
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683720/
https://www.ncbi.nlm.nih.gov/pubmed/19357641
http://dx.doi.org/10.1038/msb.2009.16
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