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Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

BACKGROUND: Misfolding- and aggregation-prone proteins underlying Parkinson's, Huntington's and Machado-Joseph diseases, namely α-synuclein, huntingtin, and ataxin-3 respectively, adopt numerous intracellular conformations during pathogenesis, including globular intermediates and insoluble...

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Detalles Bibliográficos
Autores principales:	Kvam, Erik, Nannenga, Brent L., Wang, Min S., Jia, Zongjian, Sierks, Michael R., Messer, Anne
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683928/ https://www.ncbi.nlm.nih.gov/pubmed/19492089 http://dx.doi.org/10.1371/journal.pone.0005727

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