Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, r...

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Detalles Bibliográficos
Autores principales: Kolz, Melanie, Johnson, Toby, Sanna, Serena, Teumer, Alexander, Vitart, Veronique, Perola, Markus, Mangino, Massimo, Albrecht, Eva, Wallace, Chris, Farrall, Martin, Johansson, Åsa, Nyholt, Dale R., Aulchenko, Yurii, Beckmann, Jacques S., Bergmann, Sven, Bochud, Murielle, Brown, Morris, Campbell, Harry, Connell, John, Dominiczak, Anna, Homuth, Georg, Lamina, Claudia, McCarthy, Mark I., Meitinger, Thomas, Mooser, Vincent, Munroe, Patricia, Nauck, Matthias, Peden, John, Prokisch, Holger, Salo, Perttu, Salomaa, Veikko, Samani, Nilesh J., Schlessinger, David, Uda, Manuela, Völker, Uwe, Waeber, Gérard, Waterworth, Dawn, Wang-Sattler, Rui, Wright, Alan F., Adamski, Jerzy, Whitfield, John B., Gyllensten, Ulf, Wilson, James F., Rudan, Igor, Pramstaller, Peter, Watkins, Hugh, Doering, Angela, Wichmann, H.-Erich, Spector, Tim D., Peltonen, Leena, Völzke, Henry, Nagaraja, Ramaiah, Vollenweider, Peter, Caulfield, Mark, Illig, Thomas, Gieger, Christian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683940/
https://www.ncbi.nlm.nih.gov/pubmed/19503597
http://dx.doi.org/10.1371/journal.pgen.1000504

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