Evolution of Thermal Response Properties in a Cold-Activated TRP Channel

Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in...

Descripción completa

Detalles Bibliográficos
Autores principales: Myers, Benjamin R., Sigal, Yaron M., Julius, David
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683941/
https://www.ncbi.nlm.nih.gov/pubmed/19492038
http://dx.doi.org/10.1371/journal.pone.0005741
_version_ 1782167155631980544
author Myers, Benjamin R.
Sigal, Yaron M.
Julius, David
author_facet Myers, Benjamin R.
Sigal, Yaron M.
Julius, David
author_sort Myers, Benjamin R.
collection PubMed
description Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional diversity reflecting the characteristics of an organism's ecological niche.
format Text
id pubmed-2683941
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-26839412009-06-02 Evolution of Thermal Response Properties in a Cold-Activated TRP Channel Myers, Benjamin R. Sigal, Yaron M. Julius, David PLoS One Research Article Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional diversity reflecting the characteristics of an organism's ecological niche. Public Library of Science 2009-05-29 /pmc/articles/PMC2683941/ /pubmed/19492038 http://dx.doi.org/10.1371/journal.pone.0005741 Text en Myers et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Myers, Benjamin R.
Sigal, Yaron M.
Julius, David
Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
title Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
title_full Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
title_fullStr Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
title_full_unstemmed Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
title_short Evolution of Thermal Response Properties in a Cold-Activated TRP Channel
title_sort evolution of thermal response properties in a cold-activated trp channel
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683941/
https://www.ncbi.nlm.nih.gov/pubmed/19492038
http://dx.doi.org/10.1371/journal.pone.0005741
work_keys_str_mv AT myersbenjaminr evolutionofthermalresponsepropertiesinacoldactivatedtrpchannel
AT sigalyaronm evolutionofthermalresponsepropertiesinacoldactivatedtrpchannel
AT juliusdavid evolutionofthermalresponsepropertiesinacoldactivatedtrpchannel

Ejemplares similares