Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens

Researchers routinely adopt molecular clock assumptions in conducting sequence analyses to estimate dates for viral origins in humans. We used computational methods to examine the extent to which this practice can result in inaccurate ‘retrodiction.’ Failing to account for dynamic molecular evolutio...

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Detalles Bibliográficos
Autores principales: Mok, Wendy, Seto, Kelly, Stone, Jon
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684125/
https://www.ncbi.nlm.nih.gov/pubmed/19461973
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author Mok, Wendy
Seto, Kelly
Stone, Jon
author_facet Mok, Wendy
Seto, Kelly
Stone, Jon
author_sort Mok, Wendy
collection PubMed
description Researchers routinely adopt molecular clock assumptions in conducting sequence analyses to estimate dates for viral origins in humans. We used computational methods to examine the extent to which this practice can result in inaccurate ‘retrodiction.’ Failing to account for dynamic molecular evolution can affect greatly estimating index case dates, resulting in an overestimated age for the SARS-CoV-human infection, for instance.
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spelling pubmed-26841252009-05-19 Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens Mok, Wendy Seto, Kelly Stone, Jon Evol Bioinform Online Original Research Researchers routinely adopt molecular clock assumptions in conducting sequence analyses to estimate dates for viral origins in humans. We used computational methods to examine the extent to which this practice can result in inaccurate ‘retrodiction.’ Failing to account for dynamic molecular evolution can affect greatly estimating index case dates, resulting in an overestimated age for the SARS-CoV-human infection, for instance. Libertas Academica 2007-09-26 /pmc/articles/PMC2684125/ /pubmed/19461973 Text en Copyright © 2007 The authors. http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0)
spellingShingle Original Research
Mok, Wendy
Seto, Kelly
Stone, Jon
Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens
title Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens
title_full Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens
title_fullStr Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens
title_full_unstemmed Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens
title_short Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens
title_sort non-molecular-clock-like evolution following viral origins in homo sapiens
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684125/
https://www.ncbi.nlm.nih.gov/pubmed/19461973
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AT setokelly nonmolecularclocklikeevolutionfollowingviraloriginsinhomosapiens
AT stonejon nonmolecularclocklikeevolutionfollowingviraloriginsinhomosapiens

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