An Improved Implementation of Codon Adaptation Index

Codon adaptation index is a widely used index for characterizing gene expression in general and translation efficiency in particular. Current computational implementations have a number of problems leading to various systematic biases. I illustrate these problems and provide a better computer implem...

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Detalles Bibliográficos
Autor principal: Xia, Xuhua
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684136/
https://www.ncbi.nlm.nih.gov/pubmed/19461982
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author Xia, Xuhua
author_facet Xia, Xuhua
author_sort Xia, Xuhua
collection PubMed
description Codon adaptation index is a widely used index for characterizing gene expression in general and translation efficiency in particular. Current computational implementations have a number of problems leading to various systematic biases. I illustrate these problems and provide a better computer implementation to solve these problems. The improved CAI can predict protein production better than CAI from other commonly used implementations.
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spelling pubmed-26841362009-05-19 An Improved Implementation of Codon Adaptation Index Xia, Xuhua Evol Bioinform Online Original Research Codon adaptation index is a widely used index for characterizing gene expression in general and translation efficiency in particular. Current computational implementations have a number of problems leading to various systematic biases. I illustrate these problems and provide a better computer implementation to solve these problems. The improved CAI can predict protein production better than CAI from other commonly used implementations. Libertas Academica 2007-05-17 /pmc/articles/PMC2684136/ /pubmed/19461982 Text en Copyright © 2007 The authors. http://creativecommons.org/licenses/by/3.0 This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0. (http://creativecommons.org/licenses/by/3.0)
spellingShingle Original Research
Xia, Xuhua
An Improved Implementation of Codon Adaptation Index
title An Improved Implementation of Codon Adaptation Index
title_full An Improved Implementation of Codon Adaptation Index
title_fullStr An Improved Implementation of Codon Adaptation Index
title_full_unstemmed An Improved Implementation of Codon Adaptation Index
title_short An Improved Implementation of Codon Adaptation Index
title_sort improved implementation of codon adaptation index
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684136/
https://www.ncbi.nlm.nih.gov/pubmed/19461982
work_keys_str_mv AT xiaxuhua animprovedimplementationofcodonadaptationindex
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