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Small cell cancer of the bladder: The Leon-Berard cancer centre experience

BACKGROUND: Small cell bladder carcinoma is an uncommon tumor. In this retrospective study we report our experience dealing with this disease at the Leon-Berard Cancer Centre. MATERIALS AND METHODS: We retrospectively analyzed various characteristics of small cell bladder carcinoma: patient demograp...

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Autores principales: Ismaili, Nabil, Elkarak, Fadi, Heudel, Pierre Etienne, Flechon, Aude, Droz, Jean Pierre
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684383/
https://www.ncbi.nlm.nih.gov/pubmed/19468504
http://dx.doi.org/10.4103/0970-1591.44255
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author Ismaili, Nabil
Elkarak, Fadi
Heudel, Pierre Etienne
Flechon, Aude
Droz, Jean Pierre
author_facet Ismaili, Nabil
Elkarak, Fadi
Heudel, Pierre Etienne
Flechon, Aude
Droz, Jean Pierre
author_sort Ismaili, Nabil
collection PubMed
description BACKGROUND: Small cell bladder carcinoma is an uncommon tumor. In this retrospective study we report our experience dealing with this disease at the Leon-Berard Cancer Centre. MATERIALS AND METHODS: We retrospectively analyzed various characteristics of small cell bladder carcinoma: patient demographics, histological diagnosis, disease stage, treatment effects and outcome, in 14 non-metastatic small cell bladder carcinoma patients treated at our institution between 1995 and 2006. RESULTS: The mean age at diagnosis was 60 years (range, 45-77). All patients were male. Seventy-five per cent were smokers. All had locally advanced disease. Ten patients (71.4%) were treated by cystoprostatectomy and bilateral pelvic lymph node resection, one by cystoprostatectomy alone. Two patients received neoadjuvant chemotherapy and four received adjuvant chemotherapy. One patient was treated by radiotherapy with concomitant cisplatin after transurethral resection of bladder tumor (TURBT). One patient refused surgery and was treated by chemotherapy alone. One patient was lost to follow-up after TURBT. After 49-month median follow-up, 12 patients had relapsed. Disease-free survival was 5.7 months. The most frequent sites of relapse were the retroperitoneal lymph node (seven patients) and the liver (three patients). Nine patients died of metastasis. Median overall survival was 29.5 months. Survival probability at two years was 58%. Median overall survival was 34 months in the mixed small carcinoma group, as compared with 9.5 months in the pure small cell carcinoma group (P=0.01). Mean overall survival was 27.2 months for all patients and 38.6 months for patients treated with cystectomy and adjuvant chemotherapy. CONCLUSION: To date, the optimal treatment for locally advanced small cell bladder carcinoma is not clear. Cystectomy with neoadjuvant or adjuvant chemotherapy appears as a viable option.
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spelling pubmed-26843832009-05-22 Small cell cancer of the bladder: The Leon-Berard cancer centre experience Ismaili, Nabil Elkarak, Fadi Heudel, Pierre Etienne Flechon, Aude Droz, Jean Pierre Indian J Urol Original Article BACKGROUND: Small cell bladder carcinoma is an uncommon tumor. In this retrospective study we report our experience dealing with this disease at the Leon-Berard Cancer Centre. MATERIALS AND METHODS: We retrospectively analyzed various characteristics of small cell bladder carcinoma: patient demographics, histological diagnosis, disease stage, treatment effects and outcome, in 14 non-metastatic small cell bladder carcinoma patients treated at our institution between 1995 and 2006. RESULTS: The mean age at diagnosis was 60 years (range, 45-77). All patients were male. Seventy-five per cent were smokers. All had locally advanced disease. Ten patients (71.4%) were treated by cystoprostatectomy and bilateral pelvic lymph node resection, one by cystoprostatectomy alone. Two patients received neoadjuvant chemotherapy and four received adjuvant chemotherapy. One patient was treated by radiotherapy with concomitant cisplatin after transurethral resection of bladder tumor (TURBT). One patient refused surgery and was treated by chemotherapy alone. One patient was lost to follow-up after TURBT. After 49-month median follow-up, 12 patients had relapsed. Disease-free survival was 5.7 months. The most frequent sites of relapse were the retroperitoneal lymph node (seven patients) and the liver (three patients). Nine patients died of metastasis. Median overall survival was 29.5 months. Survival probability at two years was 58%. Median overall survival was 34 months in the mixed small carcinoma group, as compared with 9.5 months in the pure small cell carcinoma group (P=0.01). Mean overall survival was 27.2 months for all patients and 38.6 months for patients treated with cystectomy and adjuvant chemotherapy. CONCLUSION: To date, the optimal treatment for locally advanced small cell bladder carcinoma is not clear. Cystectomy with neoadjuvant or adjuvant chemotherapy appears as a viable option. Medknow Publications 2008 /pmc/articles/PMC2684383/ /pubmed/19468504 http://dx.doi.org/10.4103/0970-1591.44255 Text en © Indian Journal of Urology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ismaili, Nabil
Elkarak, Fadi
Heudel, Pierre Etienne
Flechon, Aude
Droz, Jean Pierre
Small cell cancer of the bladder: The Leon-Berard cancer centre experience
title Small cell cancer of the bladder: The Leon-Berard cancer centre experience
title_full Small cell cancer of the bladder: The Leon-Berard cancer centre experience
title_fullStr Small cell cancer of the bladder: The Leon-Berard cancer centre experience
title_full_unstemmed Small cell cancer of the bladder: The Leon-Berard cancer centre experience
title_short Small cell cancer of the bladder: The Leon-Berard cancer centre experience
title_sort small cell cancer of the bladder: the leon-berard cancer centre experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684383/
https://www.ncbi.nlm.nih.gov/pubmed/19468504
http://dx.doi.org/10.4103/0970-1591.44255
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